| Autor: |
Jorge Oliveira, Rute Pereira, Mário Sousa |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Medicina Reproductiva y Embriología Clínica. 1:15-25 |
| ISSN: |
2340-9320 |
| DOI: |
10.1016/s2340-9320(15)30004-9 |
| Popis: |
Reduced sperm motility represents one of the major male causes of infertility. Ultrastructural defects in the sperm flagellum caused by genetically inherited and congenital defects are one of the main causes to reduced sperm immotility. Several molecular components have been already associated to reduced sperm motility and more are expected to be discovered, especially with the application of Next-Generation Sequencing technology. In this review we will give emphasis to the main molecular components of the sperm flagellum associated to sperm motility. We will also discuss some of ultrastructural defects in structures of sperm flagellum and the two main genetic disorders that are associated with poor sperm motility: Primary Ciliary Dyskinesia and Dysplasia of the Fibrous Sheath, with reference to genes that are known to be involved in these disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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