Bovine serum albumin catalyzed one-pot, three-component synthesis of dihydropyrano[2,3-c]pyrazole derivatives in aqueous ethanol
| Autor: | Yogesh A. Tayade, Kiran S. Dalal, Yogesh B. Wagh, Dipak S. Dalal, Darshak R. Trivedi, Bhushan L. Chaudhari |
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| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Ketone biology 010405 organic chemistry General Chemical Engineering Isatin General Chemistry Pyrazole 010402 general chemistry 01 natural sciences Aldehyde 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Biocatalysis biology.protein Organic chemistry Bovine serum albumin Malononitrile |
| Zdroj: | RSC Advances. 6:14868-14879 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c5ra13014j |
| Popis: | Bovine serum albumin (BSA) catalyzed synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one pot, three component reaction of an aldehyde/ketone/isatin, malononitrile and 3-methyl-1H-pyrazol-5-(4H)-one in H2O–EtOH (7 : 3) at ambient temperature was developed in this work. The catalyst was found to work efficiently for aldehydes, ketones and isatins to give the corresponding dihydropyrano[2,3-c]pyrazole and spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives in high yields. BSA showed a broad range of catalytic promiscuity towards various aldehydes, aromatic/aliphatic ketones and substituted isatins. The use of an environmentally benign protocol, reusability of the catalyst, avoidance of hazardous solvents, excellent yields, easy work up and no byproduct formation make BSA an attractive candidate for further applications as a biocatalyst. |
| Databáze: | OpenAIRE |
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