T8-positive lymphocytes in inflammatory infiltrates of the vessel wall in nonspecific aorto-arteritis
| Autor: | Varava Bn, Kolokol'chikova Eg, Printseva OIu, Peklo Mm |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Vascular wall
Pathology medicine.medical_specialty biology business.industry General Medicine General Biochemistry Genetics and Molecular Biology Type IV collagen medicine.anatomical_structure Smooth muscle Laminin mental disorders biology.protein medicine Cytotoxic T cell Basal membrane business Artery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 105:853-856 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/bf00842148 |
| Popis: | Artery specimens obtained during surgical manipulations from 11 patients suffering from nonspecific aortoarteritis (NAA) were studied immunohistochemically for T4, T8-positive lymphocytes, LFA-1-positive lymphocytes, basal membrane (BM) proteins: laminin and type IV collagen. T8-positive and LFA-1-positive cells were shown to be predominant in the sites of injury. The results obtained point out to the presence of cytotoxic cells in the affected arteries. The targets for such cytotoxic cells are medial smooth muscle cells rather then intimal cells, whereas intimal cells become hyperplastic, expressing BM proteins, which proves their smooth muscular origin. The above data support the suggestion on the autoimmune etiology of NAA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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