Mechanistic Insights and Safety Evaluation of the Ritter Reaction Utilizing tert-Butyl Acetate as the tert-Butyl Cation Source

Autor:	Scott W. Roberts, Stephen M. Shaw, Joe Tomaskevitch, Oliver R. Thiel, Dawn E. Cohen, Justin T. Tvetan, Jacqueline E. Milne
Rok vydání:	2012
Předmět:	Isobutylene Acetic acid chemistry.chemical_compound Acetic anhydride tert-Butyl acetate Chemistry Organic Chemistry Organic chemistry Calorimetry Physical and Theoretical Chemistry Fourier transform infrared spectroscopy Chemical reactor Ritter reaction
Zdroj:	Organic Process Research & Development. 16:2058-2063
ISSN:	1520-586X 1083-6160
DOI:	10.1021/op3000042
Popis:	The Ritter reaction utilizing tert-butyl acetate as the tert-butyl cation source was investigated by in situ FTIR and calorimetry under various reaction conditions. It was established that, when a batch mode reaction in acetic acid was performed, minimal isobutylene was evolved into the headspace, thereby avoiding pressurization of the reaction vessel. The safety of these conditions is due to the equilibrium of isobutylene and acetic acid with tert-butyl acetate. In addition, the observation of acetic anhydride provided insight into the role of acetic acid in the mechanistic pathway.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f5d46266209bcc8932b4e5d6fa1ac4d5 https://doi.org/10.1021/op3000042 Zobrazit plný text záznamu