ChemInform Abstract: A Method for the Synthesis of Hydroxamic Acids on Solid Phase

Autor:	Mark Whittaker, Sanjay R. Patel, Christopher Lewis, Christopher David Floyd
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Hydroxamic acid Wang resin stomatognathic system chemistry Phase (matter) technology industry and agriculture Organic chemistry Mitsunobu reaction General Medicine Tripeptide Cleavage (embryo) Adduct
Zdroj:	ChemInform. 28
ISSN:	0931-7597
DOI:	10.1002/chin.199711176
Popis:	Wang resin 1 was modified using a Mitsunobu reaction to give resin bound O-hydroxylamine 3. This resin was acylated and the adduct cleaved from the resin as a hydroxamic acid on treatment with TFA. Series of tripeptide, and sulfonamido 9 hydroxamic acids which act as inhibitors of metalloproteinases have been prepared. Resins more sensitive to acid cleavage can also be modified to simplify the work-up procedure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f5d2a42c7cc997f5e4ff321b5bbd2d72 https://doi.org/10.1002/chin.199711176 Zobrazit plný text záznamu Plný text