Application of vitamin D in osteoporosis therapy
| Autor: | Marina Nikolić-Đurović |
|---|---|
| Rok vydání: | 2022 |
| Zdroj: | Galenika Medical Journal. 1:85-91 |
| ISSN: | 2812-9547 2812-8575 |
| DOI: | 10.5937/galmed2203085n |
| Popis: | Vitamin D is one of the most important nutritional elements, necessary for the regulation of calcium and phosphorus metabolism and for maintaining the health of the skeletal system. It's been shown that vitamin D has an important role in maintaining normal skeletal system function by providing an appropriate balance between osteoblast and osteoclast function. Osteoporosis, ie. metabolic bone disease which increases the risk of pathological fractures, due to the changes of the microarchitecture of the skeleton, is very common consequence of long-term vitamin D deficiency. Vitamin D deficiency is considered the main cause in the pathology of certain malignancies, heart disease, hypertension, autoimmune diseases, diabetes, depression, chronic pain, osteoarthritis, osteoporosis, muscle weakness, muscle loss, periodontal disease. Vitamin D deficiency is extremely common, not only in the elderly population. It has recently been suggested that 50 nmol/l (or 20 ng/ml) is a minimum level of 25(OH)D in serum in general population especially in patients with osteoporosis to ensure optimal bone health. Vitamin D supplementation is recommended when the serum 25(OH)D concentration is below 50 nmol/l (ie 20 ng/ml) for the first 2 months 2000-4000 IU per day, and then depending on the optimal level achieved, at a dose of 1000-2000 IU. Special attention should be paid to elderly patients, with graceful constitutions with an increased risk of falls and fractures. The optimal dose supposed to ensure circulating 25(OH)D on the level of higher than 75 nmol/l. Vitamin D supplements can be given weekly, monthly or at three-month intervals. |
| Databáze: | OpenAIRE |
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