| Autor: |
K. V. Apryatina, L A Smirnova, Salomatina E.V, A. E. Mochalova, Koryagin A.S |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Journal of Nanotechnology in Diagnosis and Treatment. 2:34-41 |
| ISSN: |
2311-8792 |
| Popis: |
The present research under the application of a chitosan-coated gold nanoparticles nanosystem was made on experimental animals into the chitosan transportation property of orally administered nanostructured gold delivery into the bloodstream and its further distribution through the animals’ organs. Transportation properties are dependent on the molecular weight of chitosan: in case the molecular weight is equal or more than 30’000 an accumulation of nanoparticles is found in kidney, liver, lung and spleen as opposed to the oligomer of chitosan with the molecular weight of ~ (5-10)* 103 when the nanostructured gold is detected in kidney and liver only. The adaptogenic activity of the chitosan-coated gold nanoparticles nanosystem was revealed in conditions of hypoxia simulation. A significant feature of the nanosystem is that the nanostructured gold is completely egested from an organism within a month. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
