Terminal methyl as a one-carbon synthon: synthesis of quinoxaline derivativesviaradical-type transformation

Autor:	Huanhuan Liu, Chen Ma, Xinfeng Wang, Caixia Xie, Feiyu Zhou
Rok vydání:	2020
Předmět:	Chemistry Dimethyl sulfoxide Synthon General Chemistry Medicinal chemistry Chloride Catalysis chemistry.chemical_compound Quinoxaline Yield (chemistry) Materials Chemistry medicine Quinazoline Lewis acids and bases Amination medicine.drug
Zdroj:	New Journal of Chemistry. 44:2465-2470
ISSN:	1369-9261 1144-0546
Popis:	An iron-promoted method for the construction of pyrrolo[1,2-a]quinoxaline derivatives has been developed. Ferric chloride served as a promoter and as a Lewis acid in the reaction. Solvents provided the corresponding carbon sources simultaneously. The majority of solvents with terminal methyl groups, including ethers, amines and dimethyl sulfoxide, were reactive in the synthesis of quinoxaline derivatives at a certain yield via C–H(sp3) amination/C–O or C–N (C–S) cleavage. This method was applicable to a wide range of pyrrolo[1,2-a]quinoxaline and indolo[1,2-a]quinazoline substrates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f5c3db886d2dab6890e3558ae2c83452 https://doi.org/10.1039/c9nj04910j Zobrazit plný text záznamu