Copper-catalyzed C-C coupling and cyclization: Synthesis of benzo[4,5]imidazo[1,2-a]pyridines and benzo[4,5]imidazo[2,1-a]isoquinolines
| Autor: | Chan Sik Cho, Byeong Woo Yang, Nam Sik Yoon, Pham Duy Quang Dao |
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| Rok vydání: | 2017 |
| Předmět: |
Reaction conditions
chemistry.chemical_classification Base (chemistry) 010405 organic chemistry Organic Chemistry Iodide chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Copper Medicinal chemistry 0104 chemical sciences Catalysis Inorganic Chemistry C c coupling chemistry Materials Chemistry Copper catalyzed Physical and Theoretical Chemistry |
| Zdroj: | Journal of Organometallic Chemistry. 851:136-142 |
| ISSN: | 0022-328X |
| Popis: | 2-(2-Bromovinyl)benzimidazoles are coupled and cyclized with 1,3-diketones in DMF in the presence of a catalytic amount of copper(I) iodide and a base to afford the corresponding benzo[4,5]imidazo[1,2-a]pyridines in moderate yields. 2-(2-Bromoaryl)benzimidazoles also react with 1,3-diketones under similar reaction conditions to give benzo[4,5]imidazo[2,1-a]isoquinolines in similar yields. |
| Databáze: | OpenAIRE |
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