Complete tumor encapsulation on magnetic resonance imaging: A potentially useful imaging biomarker for better survival in solitary large hepatocellular carcinoma
| Autor: | Ronald W. Busuttil, David S.K. Lu, Myron J. Tong, Jong Seok Lee, Surachate Siripongsakun, Steven S. Raman, Jeong Kyong Lee, Sindy H Wei, Saman Sabounchi, Phillip M. Cheng, James Sayre |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Transplantation
medicine.medical_specialty Hepatology Imaging biomarker medicine.diagnostic_test business.industry medicine.medical_treatment Hazard ratio Magnetic resonance imaging Liver transplantation Milan criteria medicine.disease Surgery Hepatocellular carcinoma Predictive value of tests medicine Carcinoma Radiology business |
| Zdroj: | Liver Transplantation. 19:283-291 |
| ISSN: | 1527-6465 |
| DOI: | 10.1002/lt.23597 |
| Popis: | The aim of this study was to determine the prognostic value of complete tumor encapsulation as visualized on magnetic resonance imaging (MRI) in patients with a solitary large hepatocellular carcinoma (HCC) beyond the Milan criteria for liver transplantation (LT). Between December 2000 and March 2011, 57 patients who had a solitary HCC exceeding 5 cm in diameter at the time of initial MRI before any treatment were identified. MRI images of the patients were independently reviewed by 2 experienced readers for the presence of complete tumoral encapsulation. The medical records of the patients were reviewed for an outcome analysis. Thirty of the 57 patients had completely encapsulated HCC according to MRI. There was excellent interobserver agreement between the 2 readers for the assessment of complete encapsulation (κ=0.86). Overall survival was significantly longer for patients with completely encapsulated HCC versus patients with incompletely or nonencapsulated tumors (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text