Intractable Malabsorption With a Flat Jejunal Mucosa and Selective IgA Deficiency
| Autor: | Eleanor E. Deschner, Niall D.C. Finlayson, Karl E. Anderson |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
chemistry.chemical_classification
Pathology medicine.medical_specialty Malabsorption Jejunal mucosa Blood transfusion Hepatology business.industry medicine.medical_treatment Gastroenterology Serum iga Selective IgA deficiency medicine.disease Gluten Parenteral nutrition chemistry medicine Enteropathy business |
| Zdroj: | Gastroenterology. 67:709-716 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/s0016-5085(19)32798-2 |
| Popis: | A 13-year-old male with selective IgA deficiency, a flat jejunal mucosa, and severe, fatal malabsorption is reported. Unlike previously well described cases, there was no reponse to a gluten-free diet, and multiple forms of therapy were not helpful. The mucosal lesion was the only basis demonstrated for malabsorption, and contributing factors, such as giardiasis and bacterial overgrowth, were not present. Infusions of fresh-frozen plasma raised the serum IgA from undetectable levels to 14.5 to 16.0 mg per 100 ml, but there was no obvious beneficial effect from this. Investigations of the jejunal mucosa demonstrated proliferation of plasma cells and an increased proliferation of epithelial cells as in gluten-sensitive enteropathy. This case illustrates that in the occasional patient who initially appears to have gluten enteropathy, but does not respond to treatment, correction of coexisting selective IgA deficiency by plasma infusions may not be helpful. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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