Short pulse width in subthalamic stimulation in Parkinson's disease: a randomized, double-blind study
| Autor: | Paul Krack, Julie Anne Peron, Shahan Momjian, Emilie Tomkova Chaoui, Walid Bouthour, Vanessa Fleury, Christian Lüscher, Judit Horvath, André-Valery Zacharia, Colette Boex, Pierre R. Burkhard, Jennifer Wegrzyk |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Parkinson's disease Deep brain stimulation business.industry medicine.medical_treatment Stimulation medicine.disease Double blind study 03 medical and health sciences Subthalamic nucleus 030104 developmental biology 0302 clinical medicine Neurology Internal medicine Subthalamic stimulation medicine Cardiology Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Pulse-width modulation Muscle contraction |
| Zdroj: | Movement Disorders. 33:169-173 |
| ISSN: | 0885-3185 |
| Popis: | BACKGROUND We investigated the acute effect of short pulse widths on the therapeutic window in subthalamic nucleus deep brain stimulation in Parkinson's disease. METHODS We assessed 10 PD patients with STN-DBS at a 60-µs pulse width. We randomly and double-blindedly applied 10- to 50-µs pulse widths. The principal outcome was the therapeutic window (difference between the amplitude thresholds for visible muscle contraction and for best rigidity control). The secondary outcome was the charge per pulse (which reflects the efficiency of the stimulation) needed to control rigidity. Two-way analysis of variance and pairwise t tests were applied. RESULTS The therapeutic window widened when the pulse width shortened (r = -0.45; P |
| Databáze: | OpenAIRE |
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