Cold Autoimmune Hemolytic Anemia with Auto-Anti-Ai Specificity: 51Chromium Survival Studies
| Autor: | Arthur N. Kales, Richard A. Binder, Richard J. Davey, May H. McGinniss |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
biology business.industry government.form_of_government Incidence (epidemiology) medicine.medical_treatment Splenectomy Albumin Hematology General Medicine medicine.disease Gastroenterology Cold autoimmune hemolytic anemia Internal medicine medicine government biology.protein Immunology and Allergy Clinical significance Antibody Autoimmune hemolytic anemia business Saline |
| Zdroj: | Immunohematology. 3:17-20 |
| ISSN: | 1930-3955 |
| DOI: | 10.21307/immunohematology-2019-1124 |
| Popis: | A 65-year-old woman was found to have severe autoimmune hemolytic anemia. The patient was group A1 Rh0(D) positive. The direct antiglobulin test was strongly positive with anti-C3 and negative with anti- IgG. The serum contained two distinct IgM antibodies, auto-anti-I and auto-anti-AI. Both were reactive at 22 °C. However, the anti-AI also was reactive in saline and in albumin at 37°C. An eluate revealed anti-AI and a weak anti-L Sequential 5’Chromium survival studies were done with group OI and Al red cells. The group OI red cells survived normally (97% at 24 hours) while the group A J red cells were removed in a “two- component” pattern characteristic of IgM complementfixing antibodies (62% survival at one hour, 49% at 24 hours). Based on these observations, the patient was subsequently transfused without incidence with six group O units of washed red cells prior to splenectomy. Although auto-anti-AI has been previously reported, this is the first case to demonstrate the use of 51Cr survival studies to determine its clinical significance. |
| Databáze: | OpenAIRE |
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