INDICATORS OFTHYROID FUNCTIONOF WOMEN OF REPRODUCTIVE AGE, LIVING ON THE ECOLOGICALLY UNFAVORABLE TERRITORIES OF ARAL SEA REGION OF KAZAKHSTAN
| Autor: | Oksana D. Rymar, Anar A. Turmukhambetova, Raushan S. Dosmagambetova, Aigul Serikbayeva, Berikbay Zh. Kultanov, Zauresh Tauesheva, Lilia V. Shcherbakova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
education.field_of_study
Thyroid pathology Study thyroid business.industry Population Environmental disaster 030209 endocrinology & metabolism Reproductive age General Medicine 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Medicine Christian ministry Thyroid function business education Demography |
| Zdroj: | Clinical and experimental thyroidology. 16:28-37 |
| ISSN: | 2310-3787 1995-5472 |
| DOI: | 10.14341/ket11222 |
| Popis: | Background:The Aral crisis consider as one of the largest ecological catastrophes on the planet. TheKazakhstan part of the Aral Sea regiondeclared an environmental disaster zone. The constantly changing unfavorable environmental situation contributed to higher number of thyroid pathology and initiates the study of this problem in women of reproductive age in the AralSea area.Aims:To study thyroid function in women of reproductive age living in ecologically unfavorable territories of Kazakhstan part of the Aral Sea region.Materials and methods:The survey was conducted within scientific and technical program: “Integrated approaches in managing the health status of the population of the Aral Sea region” 2014–2016 years, performed by Ministry of Health and Social Development of the Republic of Kazakhstan. The study was cross-sectional, observational, uncontrolled and multicenter.Study included the representative sample of 2205 women of reproductive age from 18 to 49 years old living in the Aral Sea region.The levels ofTSH,FT4and AntiTPOweredetermined by the laboratory of collective use of KSMU on the Evolis Robotized System using“Tiroid-ELISA-TTG,0.23-3.4µIU/ml”, “Thyroid–ELISAfreeT4,10-23.2pmol/l”,“Tiroid ELISA – atTPO,Results:A huge number of women from environmental disadvantaged areas of the Kazakhstan part of the Aral Sea region have TSH values exceeding reference of 3.4 μI/ml.The frequency of SH was 0.2%;0.9%,0.2% in the different study areas at TTG values≥10.0 μIU/ml and freeT4 from 10to23.2 pmol/l. The frequency of MH was 2.4%;2.7%,2.5% in the studied areas at TSH values ≥10.0μIU/ml and FreeT4Conclusions:Women of reproductive age living in ecologically unfavorable territories havea high, comparable frequency of manifest hypothyroidism in the three studied zones of the Kazakhstan part of the Aral Sea region of the Republic of Kazakhstan. |
| Databáze: | OpenAIRE |
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