Synthesis, crystal structure and biological evaluation of Ni(II) complexes containing 4-chromone-N(4)-substituted thiosemicarbazone ligands
| Autor: | Rangasamy Ramachandran, Rajendran Manikandan, Periasamy Viswanathamurthi, Govindan Prakash, Sellappan Selvamurugan, Raju Nandhakumar, Akira Endo, K. Velmurugan, Paranthaman Vijayan |
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| Rok vydání: | 2016 |
| Předmět: |
biology
010405 organic chemistry Chemistry Stereochemistry Intercalation (chemistry) Plasma protein binding Crystal structure 010402 general chemistry 01 natural sciences Fluorescence spectroscopy 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound Crystallography Octahedral molecular geometry Materials Chemistry biology.protein Physical and Theoretical Chemistry Bovine serum albumin Semicarbazone DNA |
| Zdroj: | Polyhedron. 107:57-67 |
| ISSN: | 0277-5387 |
| DOI: | 10.1016/j.poly.2016.01.011 |
| Popis: | New nickel(II) complexes containing 4-chromone N (4)-substituted thiosemicarbazone ligands of the type [Ni(L 1–3 ) 2 ](NO 3 ) 2 ·H 2 O ( 1 – 3 ) [4-chromone-4-methylthiosemicarbazone (L 1 ), 4-chromone-4-phenylthiosemicarbazone (L 2 ), 4-chromone-4-cyclohexylthiosemicarbazone (L 3 )] were synthesized and characterized by analytical and various spectroscopic techniques. The single crystal X-ray diffraction study of the complex 1 revealed a distorted octahedral geometry around the metal center. The new complexes were subjected to biological investigations such as DNA/protein interaction studies and in vitro cytotoxic study against human breast cancer cell line (MCF-7). The DNA binding by fluorescence spectral study showed that the complexes bind to DNA via intercalation binding mode. Protein binding studies using fluorescence spectroscopy showed that the new complexes could bind strongly with bovine serum albumin (BSA). The complexes have good anticancer activity against MCF-7 cancer cell line due to the terminal substituted thiosemicarbazones. |
| Databáze: | OpenAIRE |
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