Sesquiterpenes from the Fruiting Bodies of Ramaria formosa and Their Human Neutrophil Elastase Inhibitory Activity

Autor:	Kwan-Chul Kim, Byung-Jo Ha, Ik-Soo Lee, Ick-Dong Yoo
Rok vydání:	2015
Předmět:	Human neutrophil biology Elastase Ramaria formosa General Chemistry General Medicine Epigallocatechin gallate Inhibitory postsynaptic potential biology.organism_classification Sesquiterpene In vitro Gomphaceae chemistry.chemical_compound chemistry Biochemistry Drug Discovery
Zdroj:	CHEMICAL & PHARMACEUTICAL BULLETIN. 63:554-557
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.c15-00051
Popis:	Two new sesquiterpene derivatives (1 and 2), ramarin A (1) and ramarin B (2), together with three known compounds (3-5) were isolated from the fruiting bodies of Ramaria formosa. The structures of the two sesquiterpenes were established by extensive spectroscopic studies and chemical evidence. The inhibitory activity of the isolated compounds (1-5) against human neutrophil elastase (HNE) was evaluated in vitro. All compounds tested inhibited HNE by 35-30% at the highest concentration used (100 µM), whereas the positive control, epigallocatechin gallate (EGCG), exhibited 60% inhibition at 100 µM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f58a63a515e59dd12c886b727ca69879 https://doi.org/10.1248/cpb.c15-00051 Zobrazit plný text záznamu