A one pot reaction cascade of in situ hydrogen peroxide production and lipase mediated in situ production of peracids for the epoxidation of monoterpenes

Autor:	Lars O. Wiemann, Sumanth Ranganathan, Volker Sieber, Tobias Gärtner
Rok vydání:	2015
Předmět:	Limonene biology Process Chemistry and Technology Substrate (chemistry) Bioengineering Biochemistry Anthraquinone Catalysis chemistry.chemical_compound chemistry Peroxy acid Anthraquinone process biology.protein Organic chemistry Lipase Hydrogen peroxide
Zdroj:	Journal of Molecular Catalysis B: Enzymatic. 114:72-76
ISSN:	1381-1177
DOI:	10.1016/j.molcatb.2014.12.008
Popis:	In this work, the epoxidation of monoterpenes in the presence of Candida antartica lipase B (CALB) by the in situ generation of peroxy acid was combined with the industrial anthraquinone (AQ) process of hydrogen peroxide production. The reaction cascade consists of two major steps: reduction of an AQ to its corresponding anthrahydroquinone (AHQ) followed by the reverse auto-oxidation step of AHQ to AQ yielding equimolar amounts of hydrogen peroxide. Temperatures for each of the steps, ratio of substrate to catalyst, possible inhibition of lipases by the AQ and reaction medium (a mixture of hydrophobic and hydrophilic solvents) to be used were investigated. By using this reaction cascade, the addition of large amounts of hydrogen peroxide was avoided and conversions to epoxides of up to 83 (±9)% for limonene, 76 (±8)% for α-pinene and 82 (±8)% for 3-carene were achieved within 16 h.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f589cd5711a87035009c19db5c95154c https://doi.org/10.1016/j.molcatb.2014.12.008 Zobrazit plný text záznamu Full Text from ScienceDirect