Preimplantation genetic testing to reduce preterm births in assisted reproductive technology
| Autor: | Joe Leigh Simpson, Svetlana Rechitsky |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Pregnancy 030219 obstetrics & reproductive medicine In vitro fertilisation Assisted reproductive technology medicine.diagnostic_test Obstetrics business.industry medicine.medical_treatment Obstetrics and Gynecology Embryo General Medicine Reproductive technology medicine.disease Embryo transfer 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure embryonic structures medicine 030212 general & internal medicine Blastocyst business Genetic testing |
| Zdroj: | International Journal of Gynecology & Obstetrics. 150:34-40 |
| ISSN: | 1879-3479 0020-7292 |
| DOI: | 10.1002/ijgo.13192 |
| Popis: | The 10% rate of preterm birth rate worldwide has not been proved amenable to reduction. Avoiding multiple embryo transfer in assisted reproductive technologies (ART) using in vitro fertilization is one unassailable method. Preimplantation genetic testing (PGT) to select only a single euploid embryo for transfer is one unequivocal way, maintaining 50%-60% pregnancy rates while avoiding twins. Contemporary methodology entails trophectoderm biopsy of a 5-6-day blastocyst, and cryopreservation of biopsied embryos while awaiting analysis by next generation sequencing. Embryo biopsy is safe, analytic validity for chromosomal analysis high, and global access to PGT high. |
| Databáze: | OpenAIRE |
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