| Popis: |
Proliferation is undoubtedly controlled by the flow of biochemical signals between various cellular molecules and classes of molecules, originating from an extracellular source and terminating at an as yet undefined intracellular target. In defining the relationship between various components of the proliferative signaling system, it will first be essential to determine the direction of information flow between them. It will then be essential to define how these molecules influence one another biochemically. Because the control of proliferation is so vital to the survival of a complex organism, it is likely that the signaling system will turn out to be subject to multiple levels of control. Neutralizing antibody and dominant inhibitory mutants of the oncogene ras have been used to make clear suggestions as to the hierarchy of information flow between at least two different classes of dominantly acting oncoproteins during proliferation. In addition, the biochemical means of this information flow has been investigated. These studies demonstrate one aspect of proliferative signaling and suggest a pattern of investigation which might be useful in studies of other components of proliferative signaling and related cellular phenomena. |
