Determination of Bactericidal Activity Spectrum of Recombinant Endolysins of ECD7, Am24, Ap22, Si3, and St11 Bacteriophages
| Autor: | A.V. Aleshkin, V V Kaminskii, S.S. Bochkareva, A M Vorob'ev, E R Zul'karneev, E O Rubalskii, Alexander Karaulov, Irina A. Kiseleva, V.A. Gushchin, A I Laishevtsev, Nataliia P Antonova, D.V. Vasina, E R Mekhtiev, M. N. Anurova, E. O. Bakhrushina |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
biology Chemistry Pseudomonas aeruginosa Klebsiella pneumoniae Lysin General Medicine Enterobacter biology.organism_classification medicine.disease_cause Campylobacter jejuni General Biochemistry Genetics and Molecular Biology Microbiology Acinetobacter baumannii Multiple drug resistance 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Salmonella enterica medicine 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 170:636-639 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The bactericidal activity of recombinant endolysins LysECD7, LysAm24, LysAp22, LysSi3 and LysSt11 was assayed in multidrug resistant strains (n=120) of Salmonella enterica, E. coli, Acinetobacter baumannii, Enterobacter spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, and Campylobacter jejuni. The assay showed that the recombinant endolysins had a wide spectrum of bactericidal activity compared to endolysins of their progenitor phages. Among examined endolysins, we selected the active pharmaceutical substances with broad spectrum of bactericidal activity. Most strains were sensitive to LysECD7 (70.7%), LysAm24 (65%), and LysAp22 (58.6%), which seems to be promising causative agents for the development of finished dosage form. |
| Databáze: | OpenAIRE |
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