Sphingomyelin-degrading pathways in human cells
| Autor: | Robert Salvayre, Thierry Levade, Nathalie Andrieu-Abadie, Nathalie Augé, Jean-Pierre Jaffrézou, Bruno Ségui, Martine Chatelut |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Ceramide Organic Chemistry Cell Biology Lipid signaling medicine.disease Biochemistry Cell biology chemistry.chemical_compound Enzyme medicine.anatomical_structure chemistry Lysosome Second messenger system medicine Sphingomyelin Niemann–Pick disease Molecular Biology Function (biology) |
| Zdroj: | Chemistry and Physics of Lipids. 102:167-178 |
| ISSN: | 0009-3084 |
| DOI: | 10.1016/s0009-3084(99)00085-7 |
| Popis: | The ubiquitous sphingophospholipid sphingomyelin (SM) can be hydrolysed in human cells to ceramide by different sphingomyelinases (SMases). These enzymes exert a dual role, enabling not only the turnover of membrane SM and the degradation of exogenous (lipoprotein) SM, but also the signal-induced generation of the lipid second messenger ceramide. This review focuses on the function(s) of the different SMases in living cells. While both lysosomal and non-lysosomal pathways that ensure SM hydrolysis in intact cells can be distinguished, the precise contribution of each of these SM-cleaving enzymes to the production of ceramide as a signalling molecule remains to be clarified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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