Immunoreactivity for cadherins, HGF/SF, met, and erbB-2 in pleural malignant mesotheliomas
| Autor: | Richard Y. Ball, P S Hasleton, P. Harvey, R. M. Warn, I Thirkettle |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Histology Immunoperoxidase medicine.medical_treatment General Medicine respiratory system Biology medicine.disease Receptor tyrosine kinase respiratory tract diseases Pathology and Forensic Medicine Pleural disease Cytokine ErbB medicine biology.protein Immunohistochemistry Hepatocyte growth factor Mesothelioma neoplasms medicine.drug |
| Zdroj: | Histopathology. 36:522-528 |
| ISSN: | 0309-0167 |
| Popis: | Aims To assess the immunoreactivity of malignant mesotheliomas for N- and E-cadherins, hepatocyte growth factor/scatter factor (HGF/SF) and the tyrosine kinase receptors, met and erbB-2. Methods and results Pleural malignant mesotheliomas were stained using a standard indirect immunoperoxidase method applied to paraffin sections. Malignant mesotheliomas were immunoreactive for N-cadherin (26/29; 90%), met (29/29; 100%) and erbB-2 (28/29; 97%). Focal immunoreactivity was present for E-cadherin in epithelioid or mixed tumours (14/25; 56%), and for HGF/SF (9/24; 38%). Conclusions Expression of N-cadherin supports the diagnosis of malignant mesothelioma and use of appropriate antibodies would be a useful addition to a diagnostic antibody panel. Focal staining for E-cadherin does not exclude mesothelioma. Signalling pathways mediated via met and erbB-2 may play a role in the growth and spread of malignant mesotheliomas. |
| Databáze: | OpenAIRE |
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