Probenecid inhibits the renal clearance and renal glucuronidation of nalidixic acid
| Autor: | Tom B. Vree, E. W. J. Vann Ewijk-Beneken Kolmer, Yechiel A. Hekster, M. van den Biggelaar-Martea |
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| Rok vydání: | 1993 |
| Předmět: |
Pharmacology
Kidney Nalidixic acid Chemistry Metabolite Acyl glucuronidation Glucuronidation Pharmaceutical Science Pharmacy General Medicine Urine urologic and male genital diseases Toxicology Probenecid chemistry.chemical_compound medicine.anatomical_structure Renal physiology medicine Pharmacology (medical) medicine.drug |
| Zdroj: | Pharmacy World & Science. 15:165-170 |
| ISSN: | 1573-739X 0928-1231 |
| DOI: | 10.1007/bf01880560 |
| Popis: | The aim of this pilot study was to demonstrate the possible inhibitory effect of probenecid on the renal glucuronidation and on the renal clearance of nalidixic acid in a human volunteer. Under acidic urine conditions, hardly any nalidixic acid is excreted unchanged (0.2%). It is excreted as acyl glucuronide (53.4%), 7-hydroxymethylnalidixic acid (10.0%), the latter's acyl glucuronide 30.9%, and 7-carboxynalidixic acid (4.2%). Under probenecid co-medication the renal glucuronidation of nalidixic acid is reduced from 53% to 16%; the renal clearance of both nalidixic acid and 7-hydroxymethylnalidixic acid are reduced (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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