Modes of action of the plant-derived phototoxin α-terthienyl in mosquito larvae
| Autor: | John T. Arnason, A.E.R. Downe, B.M. Hasspieler |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Antioxidant
biology Toxin Health Toxicology and Mutagenesis medicine.medical_treatment fungi General Medicine Aedes aegypti Glutathione Phototoxin biology.organism_classification medicine.disease_cause Lipid peroxidation chemistry.chemical_compound chemistry Biochemistry Botany medicine Glutathione disulfide Mode of action Agronomy and Crop Science |
| Zdroj: | Pesticide Biochemistry and Physiology. 38:41-47 |
| ISSN: | 0048-3575 |
| DOI: | 10.1016/0048-3575(90)90146-s |
| Popis: | The mode of action of the plant-derived phototoxic insecticide α-terthienyl (α-T), was examined in larvae of the mosquito Aedes aegypti (Linn.) (Diptera: Culicidae). Exposure of larvae to the toxin in the presence of near-ultraviolet light resulted in increased tissue levels of fluorescent breakdown products resulting from lipid peroxidation (LPO_. Control experiments confirmed that the fluorescent activity of α-T did not interfere with fluorometric determination of LPO products. Photosensitization by α-T had no significant effect on tissue levels of either total or reduced glutathione (GSH). However, levels of oxidized glutathione (glutathione disulfide) increased almost twofold as a result of α-T treatment in the presence of near-uv light. The role of LPO and GSH oxidation as indicators of mode of action of α-T and the possible role of antioxidant defense systems are discussed. |
| Databáze: | OpenAIRE |
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