ChemInform Abstract: Antiinflammatory 2-Benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones: Novel Inhibitors of COX-2

Autor:	Sorcek Ronald J, L. Churchill, Lazer Edward S, Genus J. Possanza, Charles L. Cywin, Diane Thome, A. G. Graham
Rok vydání:	2010
Předmět:	Sulfonyl chemistry.chemical_classification chemistry.chemical_compound Chemistry Oral administration Microsome General Medicine Pharmacology Isoquinoline Paw edema
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199838165
Popis:	A series of 2-benzyl-4-sulfonyl-4H-isoquinoline-1,3-diones was prepared. Members of this series are potent and selective inhibitors of cyclooxygenase-2 (COX-2) in both microsomal and cellular assays. Two representatives demonstrated activity in the carrageenan-induced paw edema model in rats upon oral administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f54a6a730de269c3f6fc944343649810 https://doi.org/10.1002/chin.199838165 Zobrazit plný text záznamu Plný text