In vitro fertilization outcomes and alcohol consumption in at-risk drinkers: The effects of a randomized intervention

Autor: Mark D. Hornstein, Stacey A. Missmer, K.F. Berry, Brooke V. Rossi, Grace Chang
Rok vydání: 2013
Předmět:
Zdroj: The American Journal on Addictions. 22:481-485
ISSN: 1055-0496
DOI: 10.1111/j.1521-0391.2013.12019.x
Popis: Alcohol use affects many aspects of reproduction in women. Moderate alcohol use (≥ 5 drinks/ week) has been associated with nearly a four-fold increase in risk of first trimester spontaneous abortion (SAB).1 Three or more episodes of binge drinking (≥ 5 drinks/episode) has been associated with an increased risk of fetal death (≥ 22 weeks gestation) and ≥ 5 drinks/week associated 3 times greater risk of fetal death (at ≥ 28 weeks).2, 3 Two studies report on the effects of alcohol use on in vitro fertilization (IVF). Klonoff-Cohen et al. found that 1 drink/day was associated with fewer oocytes retrieved, an increased risk of not becoming pregnant if they drank during the month before the attempt, and an increased risk of miscarriage if they drank 1 week before IVF.4 A more recent prospective cohort study demonstrated that women drinking at least 4 drinks/week had a 16% decrease in the odds of a live birth, but was not associated with increased odds of SAB.5 Many women stop using alcohol when they are pregnant. For those with alcohol addiction, brief interventions have proven to be successful. Pregnant women had a greater decrease in alcohol use and were more likely to be abstinent by the 3rd trimester in a brief intervention program compared to women who only had an alcohol assessment.6, 7 Due to the high costs of IVF (in terms of time, money, and emotional stress), it is critical that each cycle be optimized. Furthermore, alcohol cessation should be encouraged in the IVF population, in preparation for pregnancy. In this study, our objective was to determine if there were differences in IVF outcomes and alcohol use parameters among at-risk drinkers randomized to a brief intervention (BI) vs. assessment only (AO).
Databáze: OpenAIRE
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