Recombinant human bone morphogenetic protein -2 in combination with β-Tricalcium Phosphate and Platelet Rich Fibrin for Socket Preservation before Implant Placement

Autor: Khushboo Jeevan Durge, Vidya Sudhindra Baliga, Shilpa Banglore Srid, Prasad Vijayrao Dhadse, Gayatri Chandrakant Ragit
Rok vydání: 2020
DOI: 10.21203/rs.3.rs-42632/v1
Popis: Objectives –Periosteum is a rich source of osteoprogenitor cells, and flapless extraction technique allows for preservation of periosteum. Recombinant Bone Morphogenetic Protein-2 has osteoinductive capacity and has been exploited for bone augmentation. The aim of this study is to determine the effectiveness of rhBMP-2 for socket preservation along with β-TCP and PRF to enhance bone quality, clinically and radiographically.Results- Minimal crestal bone changes were seen at 3 months compared to baseline values; bone loss of 0.6 ± 0.13 mm at mesio-distal aspect, 0.5 ± 0.13 mm at bucco-lingual aspect. At 3 months reentry, no residual bone particulate graft were seen in any of site. Clinical hardness of bone evaluated through tactile perception while drilling, prior to implant placement, was analogous to drilling into spruce or white pine wood. Histologic analysis confirmed the absence of residual bone graft indicating new bone formation .Complete radiographic fill was seen at 3 months. The patients in current study showed adequate bone formation in grafted sockets and required no additional augmentation during implant placement. Therefore, based on the results and within the limitations of study it can be suggested that, rhBMP-2 with PRF and β-TCP can be recommended for socket preservation prior to implant placement
Databáze: OpenAIRE