Haemophagocytic syndrome in a dog with granulomatous splenitis
| Autor: | Louisa K Ho-Eckart, Erin R McQuinn, Shannon M McLeland, Austin K. Viall, Chad M Johannes |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty education.field_of_study Pathology General Veterinary 040301 veterinary sciences business.industry medicine.medical_treatment Splenectomy Population Golden Retriever 04 agricultural and veterinary sciences Histiocytic sarcoma medicine.disease 0403 veterinary science 03 medical and health sciences 030104 developmental biology Clinical investigation medicine Histopathology business education Abdominal organomegaly |
| Zdroj: | Veterinary Record Case Reports. 4 |
| ISSN: | 2052-6121 |
| DOI: | 10.1136/vetreccr-2016-000396 |
| Popis: | Summary A golden retriever dog was evaluated for cranial abdominal organomegaly. Clinical investigation found concurrent splenomegaly, anaemia, thrombocytopenia, hypoalbuminaemia and hypocholesterolaemia. Cytological evaluation of splenic aspirate samples identified a population of atypical, erythrophagocytic, mesenchymal cells. Due to the patient’s signalment, clinicopathological abnormalities and splenic cytological findings, the dog was suspected to have haemophagocytic histiocytic sarcoma. Splenectomy with splenic histopathology was performed to confirm the diagnosis. Histologically, granulomatous splenitis with erythrophagocytic macrophages was identified; a cause for splenitis was not identified. The dog was clinically diagnosed with reactive haemophagocytic syndrome secondary to splenitis. The patient clinically decompensated a month postsplenectomy and was euthanased. |
| Databáze: | OpenAIRE |
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