11 Bronchoalveolar Lavage Fluid Cytokine and Chemokine Profiles in Ventilated Preterm Infants

Autor:	W. de Jager, Luc J. I. Zimmermann, Jasper V Been, Anne Debeer, J F van Iwaarden
Rok vydání:	2010
Předmět:	Chemokine Lung biology medicine.diagnostic_test business.industry Lung injury medicine.disease Chorioamnionitis CCL5 medicine.anatomical_structure Bronchoalveolar lavage Bronchopulmonary dysplasia Pediatrics Perinatology and Child Health Immunology medicine biology.protein Interleukin 8 business
Zdroj:	Pediatric Research. 68:8-8
ISSN:	1530-0447 0031-3998
Popis:	Background and aims: Pulmonary inflammation is historically regarded a key element of the pathophysiology of bronchopulmonary dysplasia (BPD). We aimed to determine the temporal cytokine and chemokine patterns in bronchoalveolar lavage fluid (BALF) from ventilated pretem infants in the first postnatal week. Associations with exposure to chorioamnionitis and development of BPD were determined. Methods: BALF was collected in ventilated preterm infants (≤ 32 wks) on days 0, 1, 3 and 7. Using multiplex immunoassay, individual levels of 32 inflammatory mediators were quantified in each sample. Results: 93 BALF samples were obtained from 59 infants. Levels were within the detection range for the vast majority of mediators and samples. Histological chorioamnionitis was associated with significantly increased BALF cytokine and chemokine levels, most prominently so on day 0 (Figure 1A). IL-10, TNF-α, IL-1α, and IL-1β had the highest predictive ability for chorioamnionitis on day 0 (area under ROC curve >0.90; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f5270f82adc4560cf0ebfc5c7c5c0c69 https://doi.org/10.1203/00006450-201011001-00011 Zobrazit plný text záznamu