Prefabricating bone in muscle by using free tibial periosteal grafts and self-reinforced polyglycolide and poly-L-lactide pins

Autor: K. Puumanen, Tom Böhling, Nureddin Ashammakhi, Timo Waris, Heikki Pihlajamäki, P. Törmälä
Rok vydání: 2000
Předmět:
Zdroj: European Journal of Plastic Surgery. 24:19-24
ISSN: 1435-0130
0930-343X
Popis: To investigate the possibility of prefabricating bone of predetermined form in muscle using free tibial periosteal grafts and biodegradable pins, operations were performed on 12 growing rabbits. In each animal, (1) a graft around a self-reinforced polyglycolide (SR-PGA) pin, (2) a graft around a self-reinforced poly-L-lactide (SR-PLLA) pin, (3) a SR-PGA pin, and (4) a SR-PLLA pin were implanted in the dorsal muscles for 6 weeks. Histological and histomorphometric evaluations were performed. Bone formation from periosteal grafts was observed in all 12 animals. The shape of the newly-formed bone was grossly cylindrical in all specimens except one. Bone formation was stronger around the SR-PGA pins than around the SR-PLLA pins. The pins without grafts did not induce any bone formation, but fibrous tissue encapsulation instead. A mild foreign body reaction was elicited by SR-PGA pins, while it was almost absent with SR-PLLA pins. It is thus possible to prefabricate bone in a cylindrical form in growing rabbits using free tibial periosteal grafts and SR-PGA or SR-PLLA pins implanted in muscle.
Databáze: OpenAIRE
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