Quantitative insights into one-pot sequential asymmetric enzymatic catalytic processes
| Autor: | Shau-Wei Tsai |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
010405 organic chemistry
Chemistry Reaction step General Chemical Engineering Kinetics Experimental data General Chemistry Enzymatic process 010402 general chemistry 01 natural sciences Desymmetrization 0104 chemical sciences Catalysis Substrate type Organic chemistry Biological system Quantitative analysis (chemistry) |
| Zdroj: | Journal of the Taiwan Institute of Chemical Engineers. 74:79-88 |
| ISSN: | 1876-1070 |
| DOI: | 10.1016/j.jtice.2017.02.026 |
| Popis: | One-pot sequential asymmetric catalytic reactions as demonstrated in Table 1 represent one of the simplest kinds of enzymatic multiple-step catalytic processes. Yet quantitative analysis in these processes is more complicated than that in single-step kinetic resolutions or desymmetrization reactions, leading to lacking of a simple procedure for handling the kinetics in practical applications. Therefore based on the classification of substrate type and enzyme stereopreference for each reaction step, a thorough kinetic analysis for obtaining the analytical solution in each classification is carried out, with which the sufficient condition as an index for assessing an effective asymmetric enzymatic process is proposed. Case studies of monitoring the previous experimental data via the analytical solution and for fulfilling an assigned target for the intermediate or product are also addressed, showing the validity of the present analysis for the handling of kinetics in practical applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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