ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp. 007

Autor:	Cheng-Bin Cui, Qianqun Gu, Xiao-Xian Han, Weiming Zhu, Hiroyuki Osada, Hongbing Liu, Jing-Yan Gu
Rok vydání:	2005
Předmět:	biology HL60 Stereochemistry Organic Chemistry Cyclohexane conformation Actinomadura sp biology.organism_classification Ring (chemistry) Biochemistry In vitro chemistry.chemical_compound chemistry Pyran Drug Discovery medicine Staurosporine Actinomadura medicine.drug
Zdroj:	Tetrahedron Letters. 46:6137-6140
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2005.06.154
Popis:	ZHD-0501, a novel naturally occurring staurosporine analog showing anticancer activity in vitro, was isolated from the fermentation broth of a marine-derived Actinomadura sp. 007 through a bioassay-guided separation procedure and its structure elucidated by spectroscopic methods. ZHD-0501 provided the first example of staurosporin analog carrying a heterocycle fused to the pyran ring adopting a boat conformation with C-2′ and C-5′ as the bow and stern, which inhibited the proliferation of mammalian cancer A549, BEL-7402, HL60, P388, and tsFT210 cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f50e869cd74f0cd052a38bafdd5391a9 https://doi.org/10.1016/j.tetlet.2005.06.154 Zobrazit plný text záznamu Full Text from ScienceDirect