Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine treatment

Autor:	Liisa A.M. Galea, Yasukazu Kuroda, Cheryl D. Conrad, Bruce S. McEwen
Rok vydání:	1996
Předmět:	Kainic acid Hippocampus Hippocampal formation medicine.disease Behavioral Neuroscience chemistry.chemical_compound Atrophy chemistry medicine Memory impairment Chronic stress Tianeptine Psychology Neurotransmitter Neuroscience medicine.drug
Zdroj:	Behavioral Neuroscience. 110:1321-1334
ISSN:	1939-0084 0735-7044
DOI:	10.1037/0735-7044.110.6.1321
Popis:	Chronic restraint stress causes significant dendritic atrophy of CA3 pyramidal neurons that reverts to baseline within a week. Therefore, the authors assessed the functional consequences of this atrophy quickly (within hours) using the Y maze. Experiments 1-3 demonstrated that rats relied on extrinsic, spatial cues located outside of the Y maze to determine arm location and that rats with hippocampal damage (through kainic acid, colchicine, or trimethyltin) had spatial memory impairments. After the Y maze was validated as a hippocampally relevant spatial task, Experiment 4 showed that chronic restraint stress impaired spatial memory performance on the Y maze when rats were tested the day after the last stress session and that tianeptine prevented the stress-induced spatial memory impairment. These data are consistent with the previously demonstrated ability of tianeptine to prevent chronic stress-induced atrophy of the CA3 dendrites.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f4fe3825ab7598f45b7d9de515f8f2f7 https://doi.org/10.1037/0735-7044.110.6.1321 Zobrazit plný text záznamu