Cognitive impairment in Glucocerebrosidase (GBA)-associated PD: Not primarily associated with cerebrospinal fluid Abeta and Tau profiles
| Autor: | Elke Stransky, Walter Maetzler, Karin Srulijes, Ingolf Lachmann, Inga Liepelt-Scarfone, Tim W. Rattay, Claudia Schulte, Thomas Gasser, Ilona Csoti, Stefanie Lerche, Christian Deuschle, Ann-Kathrin Hauser, Kathrin Brockmann, Henrik Zetterberg, Daniela Berg, Andrea Pilotto |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cerebrospinal fluid Internal medicine mental disorders medicine Dementia Effects of sleep deprivation on cognitive performance Cognitive decline Cognitive impairment Alpha-synuclein business.industry medicine.disease 030104 developmental biology Endocrinology Neurology chemistry Neurology (clinical) business Neuroscience Glucocerebrosidase 030217 neurology & neurosurgery |
| Zdroj: | Movement Disorders. 32:1780-1783 |
| ISSN: | 0885-3185 |
| DOI: | 10.1002/mds.27199 |
| Popis: | Background A proportion of idiopathic Parkinson's disease patients (PDidiopathic) with dementia show altered CSF profiles of amyloid β (Aβ) and Tau. PD patients with Glucocerebrosidase (GBA) mutations (PDGBA) present with even more cognitive decline than seen in PDidiopathic. Objective The objective of this study was to evaluate whether CSF profiles of Aβ and tau are associated with the prominent cognitive impairment in PDGBA. Methods CSF levels of Aβ1-42, t-Tau, p-Tau, and total alpha-synuclein were assessed in 479 participants (50 PDGBA, 308 PDidiopathic, 121 healthy controls). Results Older age was associated with cognitive impairment in PDGBA and PDidiopathic. Despite prominent cognitive impairment, PDGBA showed similar CSF levels of Aβ1-42, t-Tau, and p-Tau as seen in healthy controls. In contrast, lower levels of Aβ1-42 and higher levels of t-Tau and p-Tau were associated with worse cognitive performance in PDidiopathic. Conclusions The prominent cognitive impairment in PDGBA seems not primarily associated with Aβ and Tau profiles in CSF. © 2017 International Parkinson and Movement Disorder Society |
| Databáze: | OpenAIRE |
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