RETRACTED ARTICLE: Cardiac structural remodeling in hypertensive cardiomyopathy

Autor: Nan-Nan Zhang, Jia-Lu Yao, Qing Rui, Si-Jia Sun, Ya-Feng Zhou, Yufeng Jiang, Min Chen, Lang-Biao Xu, Hua-Jia Yang
Rok vydání: 2016
Předmět:
Zdroj: Hypertension Research. 40:450-456
ISSN: 1348-4214
0916-9636
Popis: Heart failure with preserved ejection fraction (HFpEF), which is a primary driver of morbidity and mortality, accounts for approximately half of all heart failure cases. Therefore, it is essential to develop preclinical animal models for HFpEF pharmacological treatment strategies. We created a porcine model of severe hypertension and hyperlipidemia by using a combination of deoxycorticosterone acetate (DOCA, 100 mg kg-1), Western diet (WD) and angiotensin II infusion. Systolic blood pressure, echocardiography and invasive pressure-volume loop were assessed at baseline, 12 weeks and 18 weeks. A detailed histological assessment was also performed to determine the cardiac structural remodeling. Compared with controls (n=10), hypertensive animals (n=10) showed markedly higher systolic blood pressure (181 vs. 86 mm Hg) at 18 weeks. Concentric remodeling, characterized by a normal chamber size with a thicker wall, was observed in hypertensive animals. Left ventricle diastolic function showed a tendency toward decline, according to the echocardiographic data. Hemodynamic data showed that the end-diastolic pressure-volume relationship was elevated without changes in the end-systolic pressure-volume relationship. Histological results revealed that the fibrotic area in hypertensive animals (P
Databáze: OpenAIRE
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