PersistentCorynebacterium bovisInfectious Hyperkeratotic Dermatitis in Immunocompetent Epidermal-Mutantdep/depMice
| Autor: | Emily L Miedel, Natalie H Ragland, Robert W. Engelman, Andrea R Slate |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Genetically modified mouse
0303 health sciences Immune status General Veterinary 040301 veterinary sciences Mutant Outbreak Persistently infected 04 agricultural and veterinary sciences Corynebacterium bovis Biology biology.organism_classification complex mixtures Microbiology 0403 veterinary science 03 medical and health sciences 030304 developmental biology Immunodeficient Mouse |
| Zdroj: | Veterinary Pathology. 57:586-589 |
| ISSN: | 1544-2217 0300-9858 |
| Popis: | During a previously reported program-wide Corynebacterium bovis outbreak, both immunocompetent depilated ( dep/dep) mutant mice and transgenic mice that express the papillomavirus E6 oncoprotein became persistently infected with C. bovis. An orthokeratotic, hyperkeratotic, acanthotic dermatitis developed in the C. bovis–infected dep/dep mice, which remained C. bovis PCR-positive for >45 days prior to euthanasia as part of the program-wide C. bovis eradication effort. Since both affected strains of mice have altered skin homeostasis, immune status or the presence of hair may not alone be sufficient to explain strain susceptibility to C. bovis–related cutaneous disease. In order to avoid invalidation of preclinical studies due to C. bovis infection, it may be necessary to isolate immunodeficient mouse strains, implement facililty-wide surveillance for C. bovis, and sterilize equipment with vaporized hydrogen peroxide. |
| Databáze: | OpenAIRE |
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