| Autor: | Yu V Ivanova, E. I. Ten'gaev, A. N. Inyushkin |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Nucleus ambiguus
medicine.medical_specialty Kainic acid General Neuroscience Respiratory arrest Anatomy Bradypnea Biology chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine Respiration medicine Respiratory system medicine.symptom Nucleus Respiratory minute volume |
| Zdroj: | Neuroscience and Behavioral Physiology. 33:911-918 |
| ISSN: | 0097-0549 |
| DOI: | 10.1023/a:1025957007624 |
| Popis: | Experiments on anesthetized rats were performed using local chemical exclusion of neurons with kainic acid to study the relative roles of the rostral, intermediate, and caudal parts of the nucleus ambiguus in the mechanisms controlling respiration. The characteristics of the respiratory rhythm and pattern responses to chemical exclusion of different parts of this nucleus were observed. In particular, sequential exclusion of the left and right rostral parts of the nucleus ambiguus reproducibly induced significant decreases in the respiration rate and respiratory volume in the first minutes; in 83% of experiments, there was also irreversible respiratory arrest. Exclusion of symmetrical intermediate parts of the nucleus ambiguus was followed by bradypnea and decreases in pulmonary ventilation, the greatest respiratory effects being noted only after injection of kainic acid into the second symmetrical area, irreversible respiratory arrest being seen in 50% of cases. Exclusion of symmetrical caudal areas of the nucleus ambiguus resulted only in small decreases in respiratory frequency without significant changes in respiratory volume and gave rise to the smallest incidence of respiratory arrest, i.e., 33%. |
| Databáze: | OpenAIRE |
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