A phase I study of panobinostat in pediatric patients with refractory solid tumors, including CNS tumors

Autor:	Michael Michael, Lin Rigby, Grant A. McArthur, Robyn Strong, Paul Wood, Elizabeth M. Algar, David M. Ashley, Andrea Muscat
Rok vydání:	2014
Předmět:	Cancer Research biology business.industry Phase i study Pathogenesis chemistry.chemical_compound Histone Oncology chemistry Transcription (biology) Acetylation Panobinostat Cancer research biology.protein Medicine sense organs CNS TUMORS business Gene
Zdroj:	Journal of Clinical Oncology. 32:10061-10061
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2014.32.15_suppl.10061
Popis:	10061 Background: Deregulated acetylation of histones plays a key role in the pathogenesis of haematological and solid tumors by changing the transcription of genes involved in cell cycle control, ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f4dffb8a96b548c8aaa26b1cf09cb4d8 https://doi.org/10.1200/jco.2014.32.15_suppl.10061 Zobrazit plný text záznamu