Trajectory of the circulating endothelial progenitor cell levels and their association with acute rejection after heart transplantation
| Autor: | Ilona Kowalik, Katarzyna Kozar-Kamińska, Tomasz Rywik, Przemysław Leszek, Anna Wojciechowska, Agata Braniewska, Piotr Rozentryt, Małgorzata Sobieszczańska-Małek, Tomasz Zieliński, Anna Kasprzyk-Pawelec, Malgorzata Firczuk |
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| Rok vydání: | 2019 |
| Předmět: |
Heart transplantation
medicine.medical_specialty Receiver operating characteristic business.industry medicine.medical_treatment Area under the curve Lower risk Endothelial progenitor cell Quartile Internal medicine Internal Medicine medicine Cardiology Progenitor cell business Prospective cohort study |
| Zdroj: | Polish Archives of Internal Medicine. |
| ISSN: | 1897-9483 |
| Popis: | INTRODUCTION Endothelial progenitor cells (EPCs) in nontransplant settings have reparative properties. However, their role in heart transplantation (HT) is not well defined. OBJECTIVES The aim of this study was to prospectively evaluate changes in EPC levels in relation to post‑HT rejection. PATIENTS AND METHODS EPC levels were measured in 27 HT recipients for 6 months after HT. Acute cellular rejection (ACR) or antibody‑mediated rejection (AMR) were assessed by right ventricular endomyocardial biopsy. RESULTS ACR and AMR were observed in 7 (25.9%) and 6 (22.2%) patients, respectively. The ACR status at 1 month post‑HT did not differ with respect to EPC immediately post‑HT. At 1 month post‑HT in patients without ACR or AMR, EPC levels were significantly reduced compared with the measurements immediately post‑HT (P |
| Databáze: | OpenAIRE |
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