Association of kidney function and albuminuria with frailty worsening and death in very old adults
| Autor: | Nina Mielke, Alice Schneider, Muhammad Helmi Barghouth, Natalie Ebert, Markus van der Giet, Dörte Huscher, Martin K Kuhlmann, Elke Schaeffner |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Age and Ageing. 52 |
| ISSN: | 1468-2834 0002-0729 |
| Popis: | Background and objectives Studies analysing the association of albuminuria and prevalent frailty in community-dwelling very old adults are scarce and lack information on incident frailty. We investigated the association of kidney function decline and increase of albuminuria with frailty worsening or death in very old adults. Design Longitudinal analyses with biennial visits of the Berlin Initiative (cohort) Study and a frailty follow-up of 2.1 years. Setting/subjects 1,076 participants with a mean age of 84.3 (5.6) years of whom 54% were female. Methods Partial proportional odds models were used to assess the association of estimated glomerular filtration rate (eGFR) decline and/or albuminuria (albumin creatinine ratio, ACR) with frailty worsening or death. Results At frailty baseline, 1,076 participants with an eGFR of 50 (13) ml/min/1.73 m2, 48% being prefrail and 31% frail were included. After median 2.1 years, 960 (90%) participants had valid information on frailty transition: 187 (17.5%) worsened and 111 (10.3%) died. In the multivariable model, the odds of frailty worsening for participants with albuminuria in combination with eGFR Conclusions In older adults, advanced stages of CKD and albuminuria alone were associated with 2-fold odds of frailty worsening independent of death. |
| Databáze: | OpenAIRE |
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