Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-a [11C]MP4A PET study
| Autor: | Tetsuya Suhara, Makoto Higuchi, Noriko Tanaka, H. Sinotoh, Satoshi Hirano, Tsuneyoshi Ota, Ming-Rong Zhang, Hitoshi Shimada, Toshiaki Irie, Koichi Sato, Satoshi Kuwabara, Kiyoshi Fukushi, Makiko Yamada |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Dementia with Lewy bodies Area under the curve computer.software_genre medicine.disease behavioral disciplines and activities Acetylcholinesterase Psychiatry and Mental health chemistry.chemical_compound medicine.anatomical_structure chemistry Cerebral cortex Voxel Positron emission tomography Posterior cingulate mental disorders medicine Geriatrics and Gerontology Alzheimer's disease Psychology computer |
| Zdroj: | International Journal of Geriatric Psychiatry. 30:1105-1113 |
| ISSN: | 0885-6230 |
| DOI: | 10.1002/gps.4338 |
| Popis: | Objective To investigate the diagnostic performance of brain acetylcholinesterase (AChE) activity measurement using N-[11C]-methyl-4-piperidyl acetate (MP4A) and PET in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Methods Participants were 14 DLB patients, 25 AD patients and 18 age-matched healthy controls (HC). All subjects underwent PET scans and MP4A to measure regional brain AChE activity. We performed anatomical standardization of each brain image, and k3 values, an index of AChE activity, in each voxel were estimated by nonlinear least squares analysis. Volumes of interest (VOIs) were identified on parametric k3 images in frontal, temporal, parietal and occipital cortices, and in anterior and posterior cingulate gyri (ACG and PCG). In each VOI, the differential diagnostic performance between AD and DLB of k3 values was assessed by area under the curve (AUC) of the receiver-operating characteristic. Voxel-based statistical analyses were also performed. Results Mean cortical AChE activities in AD patients (−8.2% compared with normal mean) and DLB patients (−27.8%) were lower than HCs (p |
| Databáze: | OpenAIRE |
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