Acute liver failure after sevoflurane anesthesia in a pediatric patient
| Autor: | L.B. ermúdez Barrezueta, M.B. enito Gutiérrez, A.P. ino Vázquez, B.M. artínez Rafael, R.H. erraiz Cristóbal |
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| Rok vydání: | 2019 |
| Předmět: |
Abdominal pain
business.industry Encephalopathy General Medicine Hypoglycemia medicine.disease Sevoflurane 03 medical and health sciences 0302 clinical medicine Anesthesia Toxicity Anesthetic Coagulopathy medicine 030211 gastroenterology & hepatology 030212 general & internal medicine medicine.symptom Differential diagnosis business medicine.drug |
| Zdroj: | Revista Española de Anestesiología y Reanimación (English Edition). 66:474-477 |
| ISSN: | 2341-1929 |
| DOI: | 10.1016/j.redare.2019.07.002 |
| Popis: | Sevoflurane is a volatile anesthetic characterized by low toxicity and is the most used in pediatric age. Unlike other halogenated anesthetic, sevoflurane is not metabolized to reactive intermediates that lead to the formation of hepatotoxic proteins. However, a few cases of hepatotoxicity have been associated with its use. We report a case of an 11-year-old boy who developed acute liver failure after neurosurgical intervention, resection of a posterior fossa mass, under sevoflurane anesthesia and other drugs. Postoperatively, he presented abdominal pain and the laboratory tests showed markedly elevated aminotransferase levels, coagulopathy and thrombocytopenia. He had no fever, hypoglycemia or evidence of encephalopathy. The clinical evolution was favorable and after 7 days, laboratory values were completely normalized. All the possible causes of acute liver failure were evaluated and the differential diagnosis is exposed. |
| Databáze: | OpenAIRE |
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