Comparing Ion Distributions around RNA and DNA Helical and Loop-loop Motifs

Autor:	Ashley E. Marlowe, Andrey Semichaevsky, Yaroslava G. Yingling
Rok vydání:	2008
Předmět:	Molecular dynamics chemistry.chemical_compound Materials science chemistry Biophysics Nucleic acid RNA Ionic bonding Uracil DNA Thymine Ion
Zdroj:	MRS Proceedings. 1130
ISSN:	1946-4274 0272-9172
Popis:	Nucleic acid nanoparticles can self-assembly through the formation of complementary loop-loop interactions or stem-stem interactions. Presence and concentration of ions can significantly affect the self-assembly process and the stability of the nanostructure. In this paper we use explicit molecular dynamics simulations to examine the variations in cationic distributions around DNA and RNA helices and loop-loop interactions with identical sequence except for Thymine to Uracil substitution. Our simulations show that the ionic distributions are different around RNA and DNA motifs which could be related to the discrepancy in stability of loop-loop complexes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f4cdacb3bb2a4795ac28b0987338e073 https://doi.org/10.1557/proc-1130-w05-05 Zobrazit plný text záznamu Full text from SpringerLink