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This talk will focus on the synaptic and molecular mechanisms underlying direct current stimulation (DCS) and its impact on neuroplastic processes in humans, e.g. motor learning. We use a multimodal approach-in vitro slice recordings in regular mouse strains and transgenic mice, molecular biological analysis, immunohistochemistry and behavioral assessment-to tackle the mechanisms and consequences of DCS induced long-lasting synaptic potentiation (DCS-LTP), which is polarity specific, NMDA receptor dependent, and requires coupling of DCS with low-frequency synaptic activation. Similar neuroplastic effects are observable during motor learning. I will demonstrate how genetic factors across species (rodent and human) affect neuroplastic processes in general and motor learning in particular. Since DCS-LTP and learning-induced LTP may share common mechanisms, it is of great relevance to understand their interaction. This will allow a better determination of efficacy of DCS to augment motor learning and potentially neurorehabilitative processes in the future. |
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