Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: 13C-Mixed Triglyceride Breath Test versus Fecal Elastase
| Autor: | Rahma Amrani, Víctor González-Sánchez, Enrique de-Madaria, Antonio Picó, Victoria Gonzalez, Celia Trigo |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pathology Fecal elastase Endocrinology Diabetes and Metabolism Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Exocrine pancreatic insufficiency Breath test Hepatology medicine.diagnostic_test Triglyceride business.industry medicine.disease Steatorrhea Clinical trial chemistry 030220 oncology & carcinogenesis Pancreatitis 030211 gastroenterology & hepatology medicine.symptom business Area under the roc curve |
| Zdroj: | Pancreatology. 17:580-585 |
| ISSN: | 1424-3903 |
| DOI: | 10.1016/j.pan.2017.03.002 |
| Popis: | Background Pancreatic enzyme replacement therapy (PERT) is indicated in case of clinically relevant exocrine pancreatic insufficiency (EPI). Clinical trials addressing PERT have used the coefficient of fat absorption (CFA) to define EPI but this test is cumbersome to perform. Our aim was to compare two easier-to-perform tests to detect clinically relevant EPI: Fecal Elastase-1 (FE-1) and 13 C-Mixed Triglyceride Breath Test (TGBT). Methods We prospectively included 54 patients with chronic pancreatitis (CP), 24.1% operated, 29.6% had EPI. EPI was defined as a CFA Results The area under the ROC curve for FE-1/TGBT was 0.861/0.876 for the global sample, 0.842/0.794 for non-operated patients and 0.917/1 for operated patients respectively. Se, Sp, PPV and NPV for a cut-off of FE-1 Conclusions FE-1 and TGBT showed similar results for the diagnosis of EPI in CP. In non-operated CP patients, TGBT does not offer any advantage to FE-1 but in operated CP patients TGBT seems a more accurate test. |
| Databáze: | OpenAIRE |
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