New Cytotoxic Nor- and Bisnorditerpene Dilactones, Makilactones A-D, from Podocarpus macrophyllus D. Don
| Autor: | Keito Sugawara, Hyun-Sun Park, Kimihiko Sato, Yutaka Aoyagi, Haruhiko Fukaya, Toshiyuki Akiyama, Koichi Takeya, Tetsuo Koyama, Hirono Takeuehi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Podocarpus macrophyllus biology Stereochemistry Organic Chemistry biology.organism_classification Analytical Chemistry chemistry.chemical_compound chemistry visual_art visual_art.visual_art_medium Moiety Bark Spectral analysis Diterpene Podocarpaceae Two-dimensional nuclear magnetic resonance spectroscopy Single crystal |
| Zdroj: | HETEROCYCLES. 78:1453 |
| ISSN: | 0385-5414 |
| Popis: | Four new nor- and bisnorditerpene dilactones, makilactones A-D, were isolated from a MeOH extract of bark and root of Podocarpus macrophyllus D. Don (Podocarpaceae) with three known diterpene dilactones. The structures of the new nor- and bisnorditerpene dilactones having a 7:8, 9:11-dienolide moiety were determined by the spectroscopic studies, including 1D and 2D NMR spectral analysis, and single crystal X-Ray crystallographic analysis. Two of the presently isolated compounds were shown to be very strongly cytotoxic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|