Moderate hemolytic disease of the newborn due to anti-Hr0 in a mother with the D––/D–– phenotype
| Autor: | B Zupanska, B Lenkiewicz |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
biology
Bilirubin business.industry medicine.medical_treatment Antibody titer Exchange transfusion Hematology General Medicine Consanguinity 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Immunology Hemolytic disease of the newborn (ABO) biology.protein medicine Immunology and Allergy Hemoglobin Antibody business Rh blood group system |
| Zdroj: | Immunohematology. 16:109-111 |
| ISSN: | 1930-3955 |
| DOI: | 10.21307/immunohematology-2019-588 |
| Popis: | Hemolytic disease of the newborn (HDN) due to anti-Hr0 antibody is typically severe and often fatal. We report a case of moderate HDN due to anti-Hr0 in a woman with the D––/D–– phenotype. A 33-year-old woman delivered her second child who was mildly jaundiced. The highest level of bilirubin was 26.1 mg/dL on the third day postpartum and the hemoglobin concentration was 14.0 g/dL. The newborn recovered after phototherapy and no mental retardation was noticed after 1 year of follow up. An exchange transfusion was excluded due to the lack of a compatible donor and the physical condition of the mother precluded blood donation. The maternal RBCs were D+C–c–E–e–; only G and Rh29 of the Rh system were expressed. Thus, her probable phenotype was D––/D––. Her alloantibody was identified as anti-Hr0 (anti-Rh17) as it reacted with all red blood cells (RBCs) but not her own, other D-– RBCs, and Rhnull RBCs. The results of the antibody titer (64) and activity in a chemiluminescense test (CLT; 34%) were consistent with a moderate HDN. Family studies were negative for the D––/D–– phenotype and consanguinity was not proved. This is the first described case of moderate HDN due to anti-Hr0. The result of antibody activity in the CLT might be helpful in predicting the severity of HDN in other rare HDN cases. Immunohematology 2000;16:109–111. |
| Databáze: | OpenAIRE |
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