Preliminary phytochemical and biological investigations of ethanolic extract of Grewia hirsute Vahl
| Autor: | Azharul Islam, Mst. Marium Begum, Md. Amdadul Hoque, Munny Das, Md. Sohanur Rahman, Sumaiya Alam, Dipti Debnath |
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| Rok vydání: | 2019 |
| Předmět: |
biology
Traditional medicine Chemistry medicine.drug_class Analgesic biology.organism_classification 01 natural sciences Anti-inflammatory 030205 complementary & alternative medicine 0104 chemical sciences Carrageenan 010404 medicinal & biomolecular chemistry 03 medical and health sciences chemistry.chemical_compound Phytomedicine 0302 clinical medicine Grewia Complementary and alternative medicine Phytochemical Edema Castor oil medicine medicine.symptom medicine.drug |
| Zdroj: | Oriental Pharmacy and Experimental Medicine. 19:145-156 |
| ISSN: | 2211-1069 1598-2386 |
| Popis: | The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobial activities and presence of phytochemical constituents of ethanolic extract of Grewia hirsute (EGH) Vahl. Analgesic property was investigated by acetic acid, hot plate, and formalin induced writhing method, anti-inflammatory activity was assessed by xylin generated ear edema and carrageenan-induced edema in rat paw, anti-diarrheal study was conducted by castor oil and testing of gut motility using barium sulfate (BaSO4) and anti-microbial activity was assessed by disc diffusion method. In hot plate method, 250 mg/kg b.w. disclosed higher percentage latency elongation. In acetic acid-induced analgesia, percentage of writhing inhibition for 250 and 500 mg/kg b.w doses of plant extract and standard drug were 55%, 70% and 84% respectively. At later phase, 250, 500 mg/kg b.w doses of extract and standard drug showed 66.01%, 76.3% and 82.608% writhing inhibition individually in analgesia induced by formalin. In xylin-induced ear edema, 500 mg/kg b.w. dose showed noticeable inhibition (59.79%) than 250 mg/kg b.w. (48.18%). In carrageenan method, EGH demonstrated significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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