Association of Gasdermin B Gene GSDMB Polymorphisms with Risk of Allergic Diseases
Autor: | Esfir Etkina, Elza Khusnutdinova, Yuliya Yu Fedorova, Alexandra S Karunas, Galiya F Gimalova |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Genome-wide association study Single-nucleotide polymorphism General Medicine Atopic dermatitis Biology medicine.disease Biochemistry IKZF3 Human genetics 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Polymorphism (computer science) 030220 oncology & carcinogenesis Chromosomal region Immunology Genetics medicine Molecular Biology Ecology Evolution Behavior and Systematics Asthma |
Zdroj: | Biochemical Genetics. 59:1527-1543 |
ISSN: | 1573-4927 0006-2928 |
Popis: | The GSDMB gene encodes gasdermin B from the family of gasdermin domain-containing proteins involved in various cellular processes related to tumor development and progression, such as differentiation, cell cycle control and apoptosis. Previously, we conducted GWAS on asthma in the Volga-Ural region of Russia and found SNPs associated with asthma with genome-wide significance (rs9303277, rs8067378, rs2290400, rs7216389, rs4795405) and located in the chromosomal region 17q12-q21, which contains IKZF3 (IKAROS family zinc finger 3), ZPBP2 (zona pellucida binding protein-like), GSDMB (gasdermin B), ORMDL3 (orosomucoid 1-like 3) and LRRC3C (leucine-rich repeat-containing 3C) genes. In the present study, we investigated the association of SNPs of the GSDMB gene with the development of various allergic diseases and their combined manifestations in individuals of Russian, Tatar and Bashkir ethnic origin. Our results revealed that polymorphic variants rs7216389, rs2290400 and rs2305480 are associated with the development of allergic diseases as well as with asthma and asthma combined with allergic rhinitis. We did not reveal the association of rs7216389 and rs2290400 with the development of allergic rhinitis and atopic dermatitis in the groups of patients without asthma symptoms. This may reflect a more important role of these SNPs in the development of asthma. |
Databáze: | OpenAIRE |
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