Erythropoietin elevates but not voluntary wheel running in mice
| Autor: | L S Sermsakdi, Kevin M. Middleton, Theodore Garland, Scott A. Kelly, Erik M. Kolb, Mark A. Chappell |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Physiology Chemistry Oxygen transport VO2 max Treadmill exercise Aquatic Science Dose–response relationship Endocrinology Turnover Erythropoietin Insect Science Internal medicine Wheel running medicine Animal Science and Zoology Hemoglobin Molecular Biology Ecology Evolution Behavior and Systematics medicine.drug |
| Zdroj: | Journal of Experimental Biology. 213:510-519 |
| ISSN: | 1477-9145 0022-0949 |
| DOI: | 10.1242/jeb.029074 |
| Popis: | SUMMARYVoluntary activity is a complex trait, comprising both behavioral (motivation, reward) and anatomical/physiological (ability) elements. In the present study, oxygen transport was investigated as a possible limitation to further increases in running by four replicate lines of mice that have been selectively bred for high voluntary wheel running and have reached an apparent selection limit. To increase oxygen transport capacity, erythrocyte density was elevated by the administration of an erythropoietin (EPO) analogue. Mice were given two EPO injections, two days apart, at one of two dose levels (100 or 300 μg kg–1). Hemoglobin concentration ([Hb]), maximal aerobic capacity during forced treadmill exercise () and voluntary wheel running were measured. [Hb] did not differ between high runner (HR) and non-selected control (C) lines without EPO treatment. Both doses of EPO significantly (P |
| Databáze: | OpenAIRE |
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